Our ingredients Azelaic acid

Azelaic acid is produced naturally by yeasts that lives on skin. It is effective for treating acne and rosacea as well as improving skin texture and reducing pigmentation.

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Grade Indication Size of effect Comments
A Acne treatment Strong Reduces comedones, papules and pustules, and is suitable for long term maintenance therapy
A Rosacea treatment Strong Effective treatment for rosacea
A Melasma treatment Strong 20% azelaic acid cream lightens melasma as effectively as 4% hydroquinone.
B Skin lightening Moderate Depigments the skin by killing abnormal melanocytes and inhibiting tyrosinase. Not effective against age spots, however.
What is Azelaic acid?
How does Azelaic acid work?
What are the side-effects of using Azelaic acid?

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the science of Azelaic acid

Acne treatment

Azelaic acid is recommended as a useful second line or adjunctive treatment for mild to moderate severity acne. It is anti-inflammatory and antibacterial and also works actively against comedones. Azelaic acid is particularly useful where there is post-inflammatory hyperpigmentation because of its lightening effect, and may be better tolerated than tretinoin.[1][2][3]


A clinical trial in Leeds, UK, matched 20 pairs of patients to 20% azelaic acid against its base, applied twice daily. They found a significant reduction in inflamed and non-inflamed lesion count compared to placebo. Azelaic acid was also shown to reduce the density of the bacterium species propionibacterium[5].

In a trial of 289 patients with comedonal acne, azelaic acid was equally as effective as tretinoin at reducing the number of comedones, but was tolerated better than tretinoin, causing fewer local side effects[1].

In one study, 55 women with adult acne (18-45) were received either azelaic acid or adapalene gel. Treatment with Azelaic acid was found to be non-inferior (within 50% margins) compared to adapalene gel, but dryness and scaling were not as severe as the adapalene group[6].

Azelaic acid has been shown to be a good option for patients with mild-to-moderate acne, associated with moderate-to-severe post inflammatory hyperpigmentation, as it has been shown to reduce both the acne and the post-inflammatory hyperpigmentation[7].

Rosacea

A Cochrane systematic review pooled results from five randomised controlled trials with over 1,000 patients comparing azelaic acid compared to placebo. They found high quality evidence that azelaic acid improved rosacea from the patients’ and doctors’ point of view, and there was a significant improvement in erythema (redness) compared to placebo. There was also moderate strength evidence that showed azelaic acid reduced lesion count compared to placebo[4].

References